Progress in the application of freeze-drying technology in vaccine research

No.1 On vaccines

Vaccines are immunological preparations used to prevent infectious diseases, made by artificially attenuating, inactivating, or using genetic modification methods on pathogens (such as bacteria, rickettsiae, viruses, etc.) and their metabolic products. Depending on the production process, vaccines can be categorized into inactivated vaccines, live attenuated vaccines, toxoid vaccines, subunit vaccines, mRNA vaccines, and viral vector vaccines.

Vaccines play a crucial role in the prevention and control of infectious diseases. However, the stability of vaccines poses significant challenges in their use. Factors such as temperature and humidity during transportation and storage can affect vaccine efficacy. Vaccines are typically administered in aqueous solution, but liquid vaccines have disadvantages like easy hydrolysis and poor stability. In contrast, solid vaccines help mitigate instability to some extent, better preserving their biological activity while also exhibiting good rehydration capabilities, making them easier to store and transport.

No.2 Traditional drying VS freeze-drying

Traditional drying methods tend to reduce vaccine activity during the drying process. Therefore, in the 1950s, scientists began using freeze-drying (freeze-dry-ing, FD) technology to dry vaccines. FD technology effectively overcomes the thermodynamic instability of antigenic components in vaccines, providing an efficient method for vaccine preparation that ensures the stability of physical and chemical properties during preparation and storage. It is currently one of the most commonly used drying methods for biological products. Freeze-drying technology (FD) involves freezing liquid substances and then, under vacuum conditions, directly converting the frozen water from a solid to a gaseous state, thereby removing moisture from the sample. Since FD removes water through low-temperature solid-state conditions, it effectively preserves the structure and active components of the product, making it widely applied in pharmaceuticals, food, and biotechnology fields. Currently, common freeze-dryers used in experimental research include two models: bell jar and in-situ, which can be combined with various functions to meet actual customer needs. For vaccine development, in-situ freeze-dryers are more suitable.

No.3 New cheddar freeze-dried

The SCIENTZ-F series in-situ freeze-drying machine is specifically designed for processing samples with complex temperature profiles (especially pharmaceuticals, microbial products, and precious herbs). It can be used for pilot-scale trials, intermediate-scale production, and small-scale manufacturing in enterprises, particularly suitable for exploring freeze-drying processes. The product has been widely applied in pharmaceutical R&D, food freeze-drying process research, new material studies, and more, combining functionality with cost-effectiveness.

Overall performance: safe and efficient, environmental protection and cleaning

Heating system: silicone oil medium, uniformity is good

Refrigeration system: rapid refrigeration, clear visibility

Control system: intelligent control, true color display

Dual-chamber system: anti-corrosion cold trap,

supports pre-freezing vacuum system:Vacuum controllable, intelligent protection

As a global sample preparation expert, Scientz Bio has been deeply engaged in freeze-drying technology for many years. Starting from the actual needs of users, it can provide users with high-efficiency, cost-effective products and solutions. The product has complete functions, welcome to consult.