Tablet Disintegration Apparatus

Tablet disintegration apparatus are used to test how a drug in pellet form will disintegrate in solution. Disintegration testers help in evaluation of disintegration capability of formulations (ex: tablets) and quality control of different dosage forms in pharmaceutical companies. 

The mechanism of tablet disintegration:

① Mechanism of forming corrosive pores: Soluble ingredients contained in the tablet dissolve quickly after contact with water to form corrosive pores.

② Solid bridge fracture mechanism: After water penetrates the tablet, the "solid bridge" dissolves and the binding force disappears.

③ Gas generation mechanism: The tablets containing effervescent disintegrants produce CO2 gas when they encounter water.

④ Water absorption and swelling mechanism: The disintegrant swells with water, the volume of editing and finishing increases, and the binding force of the tablet is destroyed.

⑤ Moist heat mechanism: The tablet absorbs water and produces moist heat, which is the expansion of the air in the tablet.

FAQ

1.What is disintegration test of tablets?

Although it cannot measure the amount of drug released, disintegration is, for IR tablets, the first process before dissolution can occur. Disintegration is a physical process related to the mechanical breakdown of a tablet or granulate particle into smaller particles.

2.Does the speed at which effervescent tablets disintegrate change with the temperature of the water?

Chemists get an indication of the relative rate of reaction at different temperatures that states that there is a doubling of the rate for every 10 ℃ rise in temperature.

So yes, the rate of disintegration and effervescence increases with rise in temperature by approximately, said amount.

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